Where We're Hot, They're Not

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Science  01 Apr 2005:
Vol. 308, Issue 5718, pp. 60-62
DOI: 10.1126/science.1110903

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Homologous recombination is the exchange of material between chromosome pairs during meiosis. As Jorde discusses in his Perspective, new work ( Winckler et al.) reveals a surprising finding about the recombination hotspots of the human and chimp genomes. Despite about 99% identity between the DNA sequences of these two species, there is virtually no overlap in the locations of recombination hotspots. Jorde discusses the possible reasons for this unexpected finding.