PerspectiveCell Biology

Kinasing and Clipping Down the NF-κB Trail

Science  01 Apr 2005:
Vol. 308, Issue 5718, pp. 65-66
DOI: 10.1126/science.1110902

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Summary

Activation of T cells is a key requirement for a successful innate or adaptive immune response to pathogenic insult. T cell stimulation results in activation of the master transcription factor NF-B by a complicated signaling pathway that is only partially understood. In their Perspective, van Oers and Chen discuss new findings that implicate the kinase PDK1 ( Lee et al.) and a caspase (Su et al.) as crucial players in the T cell signaling pathway that activates NF-B.