PerspectiveCell Biology

GSK-3β and Microtubule Assembly in Axons

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Science  08 Apr 2005:
Vol. 308, Issue 5719, pp. 211-214
DOI: 10.1126/science.1110301

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Summary

GSK-3is a master kinase that controls many different aspects of nervous system development and function and has been implicated in neurodegeneration. In a Perspective, Zhou and Snider discuss emerging evidence that reveals how GSK-3regulates the morphogenesis of axons by controlling the assembly of microtubules that are needed for axonal extension.