PerspectiveCell Biology

Of Grainy Heads and Broken Skins

Science  15 Apr 2005:
Vol. 308, Issue 5720, pp. 364-365
DOI: 10.1126/science.1112050

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Many studies have revealed the signaling pathways and transcription factors involved in the reepithelialization of damaged epithelia, but less is known about the pathways involved in the repair of the outer layer of the surface barrier. In his Perspective, Harden discusses two new studies (Ting et al., Mace et al.) that reveal the part played by highly conserved members of the Grainy head transcription factor family in the repair of the surface-barrier outer layer of flies (the cuticle) and mice (the stratum corneum).