Unveiling the Mechanisms of Cell-Cell Fusion

See allHide authors and affiliations

Science  15 Apr 2005:
Vol. 308, Issue 5720, pp. 369-373
DOI: 10.1126/science.1104799

You are currently viewing the abstract.

View Full Text


Cell-cell fusion is fundamental to the development and physiology of multicellular organisms, but little is known of its mechanistic underpinnings. Recent studies have revealed that many proteins involved in cell-cell fusion are also required for seemingly unrelated cellular processes such as phagocytosis, cell migration, axon growth, and synaptogenesis. We review advances in understanding cell-cell fusion by contrasting it with virus-cell and intracellular vesicle fusion. We also consider how proteins involved in general aspects of membrane dynamics have been co-opted to control fusion of diverse cell types by coupling with specialized proteins involved in cell-cell recognition, adhesion, and signaling.

View Full Text