PerspectiveCell Biology

A Fishing Buddy for Hypothesis Generators

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Science  22 Apr 2005:
Vol. 308, Issue 5721, pp. 504-506
DOI: 10.1126/science.1110535

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Understanding how signaling proteins interact in a giant intracellular network to control numerous cellular processes is the goal of many biologists. In their Perspective, Brent and Lok discuss a study that takes us a step closer to accomplishing this goal. The Perspective authors describe the application of Bayesian networks and computational methods to elucidating interactions among the signaling proteins in individual human T cells ( Sachs et al.)