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The Intracellular Fate of Salmonella Depends on the Recruitment of Kinesin

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Science  20 May 2005:
Vol. 308, Issue 5725, pp. 1174-1178
DOI: 10.1126/science.1110225

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Abstract

Salmonella enterica causes a variety of diseases, including gastroenteritis and typhoid fever. The success of this pathogen depends on its capacity to proliferate within host cells in a membrane-bound compartment. We found that the Salmonella-containing vacuole recruited the plus-end–directed motor kinesin. Bacterial effector proteins translocated into the host cell by a type III secretion system antagonistically regulated this event. Among these effectors, SifA targeted SKIP, a host protein that down-regulated the recruitment of kinesin on the bacterial vacuole and, in turn, controlled vacuolar membrane dynamics.

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