Review

Allosteric Mechanisms of Signal Transduction

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Science  03 Jun 2005:
Vol. 308, Issue 5727, pp. 1424-1428
DOI: 10.1126/science.1108595

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Abstract

Forty years ago, a simple model of allosteric mechanisms (indirect interactions between distinct sites), used initially to explain feedback-inhibited enzymes, was presented by Monod, Wyman, and Changeux. We review the MWC theory and its applications for the understanding of signal transduction in biology, and also identify remaining issues that deserve theoretical and experimental substantiation.

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