Opposites Attract in Differentiating T Cells

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Science  10 Jun 2005:
Vol. 308, Issue 5728, pp. 1563-1565
DOI: 10.1126/science.1114167

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Depending on specific cues from the pathogen they are exposed to, progenitor T cells differentiate into T helper 1 (T1) or T helper 2 (T2) cells. Like other antagonistic cell differentiation pathways, T1 and T2 differentiation are mutually exclusive, with positive regulators of one pathway acting as negative regulators of the opposing pathway. In their Perspective, Bix et al. describe new data on how direct connections between elements in the two pathways might drive positive and negative crosstalk.