Special Reviews

Uterine Fibroids: The Elephant in the Room

Science  10 Jun 2005:
Vol. 308, Issue 5728, pp. 1589-1592
DOI: 10.1126/science.1112063

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Abstract

Uterine fibroids (leiomyomas) have historically been viewed as important chiefly as the major indication for hysterectomy. As new therapies are developed, the heterogeneity of this disease becomes therapeutically relevant. An awareness of the role of genetics, the extracellular matrix, and hormones in tumor etiology is key to understanding this disease.

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