CELL BIOLOGY: Perfect Peroxisome Partitioning

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Science  17 Jun 2005:
Vol. 308, Issue 5729, pp. 1717b
DOI: 10.1126/science.308.5729.1717b

During successful cell division, mother and daughter cells arrive at an equitable allocation of each type of membrane-bounded organelle. Molecular mechanisms that guarantee faithful organelle partitioning in budding yeast involve the polarized actin cytoskeleton and myosin-related motors and are well established for mitochondria, the vacuole, secretory vesicles, and the endoplasmic reticulum. However, peroxisomes are low-copy-number organelles involved in lipid metabolism whose inheritance has been less well characterized.

Fagarasanu et al. examined the role of a peripheral peroxisomal membrane protein, Inp1p (for inheritance of peroxisomes protein 1). In budding yeast, overexpression of Inp1 led to the failure of efficient peroxisome delivery to the bud, whereas deletion of the INP1 gene often left the mother cell without any peroxisomes. It appears that Inp1p helps to anchor peroxisomes within cells, and having the right amount of it is critical to a fair and harmonious division of accumulated assets. — SMH

J. Cell Biol. 169, 765 (2005).

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