Continuous Cell Culture on a Chip

Science  01 Jul 2005:
Vol. 309, Issue 5731, pp. 15
DOI: 10.1126/science.309.5731.15n

A chip-based “microchemostat” has been devised by Balagaddé et al. (p. 137) that allows continuous culture of bacterial cells in a device about 4 cm long. An active biofilm control system that uses a microfluidic plumbing network to remove adhering cells allow for continuous operation. This technology allows automated, long-term steady-state culturing of planktonic cells while allowing observation of cell properties (such as morphological diversity) with single-cell resolution.

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