Nippy Inoculation

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Science  01 Jul 2005:
Vol. 309, Issue 5731, pp. 21
DOI: 10.1126/science.309.5731.21b

For a vaccine to generate protective immunity at a level comparable to that produced by an infection, one or more secondary booster shots over an extended period of time may be required. Thus, finding ways by which the initially primed memory T cells might be more efficiently bolstered could help to increase vaccine efficacy.

Badovinac et that mice vaccinated with dendritic cells that have been coated with peptides derived from the bacterium Listeria monocytogenes could mobilize a memory CD8+ T cell response to a booster challenge considerably faster than mice given an attenuated bacteria vaccine. Furthermore, the dendritic cell-vaccinated mice also showed significantly greater resistance to infectious bacteria, consistent with an increased level of protective immunity. Vigorous memory responses were also generated to a range of other booster immunizations, including those from a noninfectious source, and were apparent even toward weak antigens. Vaccination with coated dendritic cells in this setting was at its most efficacious when inflammatory signals were minimal, which appeared to accelerate the rate at which CD8+ T cells acquired a memory phenotype during the priming phase. — SJS

Nat. Med. 10.1038/nm1257 (2005).

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