Now Presenting: γδ T Cells

Science  08 Jul 2005:
Vol. 309, Issue 5732, pp. 252-253
DOI: 10.1126/science.1115264

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T lymphocytes of the immune system require that foreign molecules called antigens be presented to them for their clonal expansion and stimulation of their effector functions. Presentation of peptide antigens to activate naïve T cells was previously thought to reside solely in dendritic cells. A Perspective by Modlin and Sieling describes new evidence that challenges this premise. A population ofT cells efficiently presents peptide antigens toT cells, the predominant T cell population in mammals. This suggests thatT cells function as part of innate (rapid, short-lived) and adaptive (slower, long-lasting) immunity, the two arms of the immune response.