DATABASES: The Other Hepatitis

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Science  22 Jul 2005:
Vol. 309, Issue 5734, pp. 539
DOI: 10.1126/science.309.5734.539d

First identified in 1989, the hepatitis C virus lurks in about 4 million U.S. residents. The insidious pathogen can destroy the liver or provoke cancer; it's responsible for about 50% of liver tumors. This site from Los Alamos National Laboratory in New Mexico offers two databases for researchers interested in the virus. One database lets you troll more than 30,000 full and partial genome sequences from samples collected around the world. You can search by viral subtype, geographic location, route of infection, or other variables. Tools help you build evolutionary trees based on your own sequences and perform other analyses. The site's immunology database lists viral segments that trigger a response from T cells and describes antibodies that latch onto the virus.

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