DATABASE: When Proteins Get Fat

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Science  29 Jul 2005:
Vol. 309, Issue 5735, pp. 677c
DOI: 10.1126/science.309.5735.677c

Bacteria rely on protein-lipid combinations known as lipoproteins to glom onto surfaces, sense their surroundings, slurp up nutrients, shuttle DNA to other cells, and perform other life tasks. Researchers can analyze more than 270 of the molecules at DOLOP, a database from the Medical Research Council Laboratory of Molecular Biology in Cambridge, U.K. Entries describe each protein, indicate its size and function, and provide links to the Swiss-Prot database, where you can parse the molecule's sequence and structural features. The site also explains the synthesis of lipoproteins and describes the lipobox, a characteristic amino acid string to which lipids attach.

www.mrc-lmb.cam.ac.uk/genomes/dolop

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