PerspectiveMicrobiology

Translocation of Anthrax Toxin: Lord of the Rings

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Science  29 Jul 2005:
Vol. 309, Issue 5735, pp. 709-710
DOI: 10.1126/science.1116630

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Summary

[HN11] Many microorganisms have evolved ingenious ways of shipping toxic proteins into target cells. In his Perspective, von Heijne discusses a study by Krantz et al. that reveals how anthrax toxin gets into a cell. A ring of aromatic amino acids in a pore formed by anthrax toxin helps unfold other anthrax toxin proteins and facilitate their translocation across the cell membrane.