PerspectiveDevelopmental Biology

Rac1 Up for Epidermal Stem Cells

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Science  05 Aug 2005:
Vol. 309, Issue 5736, pp. 890-891
DOI: 10.1126/science.1117192

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Summary

Stem cells in the skin and hair follicle are responsible for continual renewal of these tissues. Identification of genes involved in the proliferation and differentiation of stem cells is of paramount importance for understanding skin homeostasis and tumorigenesis. In their Perspective, Dotto and Cotsarelis discuss how the gene encoding Rac1 appears vital for maintaining the stem cells in the skin.