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Direct Control of Germline Stem Cell Division and Cyst Growth by Neural Insulin in Drosophila

Science  12 Aug 2005:
Vol. 309, Issue 5737, pp. 1071-1073
DOI: 10.1126/science.1111410

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Abstract

Stem cells reside in specialized niches that provide signals required for their maintenance and division. Tissue-extrinsic signals can also modify stem cell activity, although this is poorly understood. Here, we report that neural-derived Drosophila insulin-like peptides (DILPs) directly regulate germline stem cell division rate, demonstrating that signals mediating the ovarian response to nutritional input can modify stem cell activity in a niche-independent manner. We also reveal a crucial direct role of DILPs in controlling germline cyst growth and vitellogenesis.

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