TOOLS: Snooping for SNPs

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Science  12 Aug 2005:
Vol. 309, Issue 5737, pp. 995
DOI: 10.1126/science.309.5737.995c

The genome's typos, single-nucleotide polymorphisms (SNPs), are one-letter changes in DNA that can signal susceptibility to diseases. WatCut from the University of Waterloo in Canada helps pinpoint SNPs in DNA samples. Users enter a SNP-containing DNA sequence, and WatCut identifies restriction enzymes that will chop the segment. The site can also hunt for silent mutations that allow a restriction enzyme to slice a sequence but that don't change the amino acids the sequence codes for.

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