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Fewer Genes, More Noncoding RNA

Science  02 Sep 2005:
Vol. 309, Issue 5740, pp. 1529-1530
DOI: 10.1126/science.1116800

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Abstract

Recent studies showing that most “messenger” RNAs do not encode proteins finally explain the long-standing discrepancy between the small number of protein-coding genes found in vertebrate genomes and the much larger and ever-increasing number of polyadenylated transcripts identified by tag-sampling or microarray-based methods. Exploring the role and diversity of these numerous noncoding RNAs now constitutes a main challenge in transcription research.

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