Dietary Factors and Immunological Consequences

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Science  09 Sep 2005:
Vol. 309, Issue 5741, pp. 1682-1683
DOI: 10.1126/science.1118340

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The lipid sphingosine 1-phosphate acts through cell surface receptors expressed on the surface of lymphocytes. In his Perspective, Hla discusses how the degradative action of sphingosine 1-phosphate lyase in tissues helps establish the steep vascular gradient of this lipid. Inhibition of the lyase by dietary factors disrupts the gradient, reducing T cell trafficking and thereby supressing immunity.