Report

Ongoing Adaptive Evolution of ASPM, a Brain Size Determinant in Homo sapiens

Science  09 Sep 2005:
Vol. 309, Issue 5741, pp. 1720-1722
DOI: 10.1126/science.1116815

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Abstract

The gene ASPM (abnormal spindle-like microcephaly associated) is a specific regulator of brain size, and its evolution in the lineage leading to Homo sapiens was driven by strong positive selection. Here, we show that one genetic variant of ASPM in humans arose merely about 5800 years ago and has since swept to high frequency under strong positive selection. These findings, especially the remarkably young age of the positively selected variant, suggest that the human brain is still undergoing rapid adaptive evolution.

View Full Text

Cited By...