PerspectiveCell Biology

A Fungal Achilles' Heel

+ See all authors and affiliations

Science  30 Sep 2005:
Vol. 309, Issue 5744, pp. 2175-2176
DOI: 10.1126/science.1119321

You are currently viewing the summary.

View Full Text

Summary

The ability of pathogenic microbes to rapidly acquire resistance to antimicrobial agents is a serious threat to human health. In a Perspective, Heitman discusses the study by Cowen and Lindquist (in this issue) that defines a role for two proteins, Hsp90 and calcineurin, in drug tolerance and resistance in pathogenic fungi, providing a novel therapeutic foothold.