PerspectiveCell Biology

A Fungal Achilles' Heel

See allHide authors and affiliations

Science  30 Sep 2005:
Vol. 309, Issue 5744, pp. 2175-2176
DOI: 10.1126/science.1119321

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


The ability of pathogenic microbes to rapidly acquire resistance to antimicrobial agents is a serious threat to human health. In a Perspective, Heitman discusses the study by Cowen and Lindquist (in this issue) that defines a role for two proteins, Hsp90 and calcineurin, in drug tolerance and resistance in pathogenic fungi, providing a novel therapeutic foothold.