PerspectiveCell Biology

A Fungal Achilles' Heel

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Science  30 Sep 2005:
Vol. 309, Issue 5744, pp. 2175-2176
DOI: 10.1126/science.1119321

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The ability of pathogenic microbes to rapidly acquire resistance to antimicrobial agents is a serious threat to human health. In a Perspective, Heitman discusses the study by Cowen and Lindquist (in this issue) that defines a role for two proteins, Hsp90 and calcineurin, in drug tolerance and resistance in pathogenic fungi, providing a novel therapeutic foothold.