Peptides Seeing Polymers

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Science  07 Oct 2005:
Vol. 310, Issue 5745, pp. 19
DOI: 10.1126/science.310.5745.19b

The recognition of nonbiological material surfaces by peptides can be useful for controlling material growth or providing a scaffold for surface modification. Examples include mineral surfaces, and peptide motifs that recognize particular polymer compositions have been reported. Serizawa et al. investigated the binding of a large library (~109 members) of short peptides (seven amino acids) and found that a few sequences can selectively latch onto the stereochemistry of the backbone of poly(methyl methacrylate) (PMMA). One peptide, containing an -Arg-Pro-Thr-Arg-motif, had six times greater affinity for isotactic PMMA (with the side chains all on one side of the backbone) over the syndiotactic form (in which the side chains alternate). Modeling suggests that the basic ends of the extended peptide motif recognize a repeat of two to six units in the PMMA chain. — PDS

J. Am. Chem. Soc. 10.1021/ja054402o (2005).

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