PerspectiveGenetics

Motivating Hotspots

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Science  14 Oct 2005:
Vol. 310, Issue 5746, pp. 247-248
DOI: 10.1126/science.1120154

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Summary

Only recently have we begun to characterize fine-scale recombination rates in mammals. In her Perspective, Przeworski discusses the work by Myers et al. in which linkage disequilibrium data have been used to produce a high-resolution recombination map for most of the human genome. More than 25,000 putative hotspots have been identified, as well as the first motifs that appear to influence their intensity.