Report

Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS

+ See all authors and affiliations

Science  14 Oct 2005:
Vol. 310, Issue 5746, pp. 314-317
DOI: 10.1126/science.1117728

You are currently viewing the abstract.

View Full Text

Abstract

Calorie restriction extends life span in organisms ranging from yeast to mammals. Here, we report that calorie restriction for either 3 or 12 months induced endothelial nitric oxide synthase (eNOS) expression and 3′,5′-cyclic guanosine monophosphate formation in various tissues of male mice. This was accompanied by mitochondrial biogenesis, with increased oxygen consumption and adenosine triphosphate production, and an enhanced expression of sirtuin 1. These effects were strongly attenuated in eNOS null-mutant mice. Thus, nitric oxide plays a fundamental role in the processes induced by calorie restriction and may be involved in the extension of life span in mammals.

View Full Text

Related Content