PerspectiveEvolution

Changing the Cofactor Diet of an Enzyme

+ See all authors and affiliations

Science  21 Oct 2005:
Vol. 310, Issue 5747, pp. 454-455
DOI: 10.1126/science.1120279

You are currently viewing the summary.

View Full Text

Summary

In all life, NADis the cofactor for an enzyme used in leucine biosynthesis. In their Perspective, Ellington and Bull discuss how a five-amino acid change in the enzyme switches the cofactor to NADP, with normal activity in vitro. Yet NADPuse in vivo comes at an unavoidable cost, explaining the conservation of cofactor specificities in natural enzymes.

Related Content