Separation of Conjoined Hormones Yields Appetite Rivals

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Science  11 Nov 2005:
Vol. 310, Issue 5750, pp. 985-986
DOI: 10.1126/science.1121214

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In their Perspective, Nogueiras and Tschöp discuss the study of Zhang et al. that has identified obestatin, a new hormone regulator of energy balance. Obestatin suppresses food intake, body weight gain, and gastrointestinal motility in rodents. The paradox is that obestatin is derived from a precursor peptide that also yields ghrelin, a hormone that increases appetite and body weight.