DATABASE: Out of Synch

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Science  18 Nov 2005:
Vol. 310, Issue 5751, pp. 1099
DOI: 10.1126/science.310.5751.1099c

People with long QT syndrome can faint or die suddenly because their ventricles are prone to rapid contractions. The disease results from mutations that make heart muscle cells repolarize tardily after firing. Find out more about the DNA defects behind long QT syndrome and eight other arrhythmias at Gene Connection for the Heart, hosted by the IRCCS Fondazione Salvatore Maugeri in Pavia, Italy. The database describes the diseases and profiles each mutation, indicating its location and how it changes the gene and the protein. Included is a diagram showing where mutations alter the SCN5A protein, which allows sodium ions into heart cells during contraction.

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