TOOLS: Stacking Gene Chips

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Science  18 Nov 2005:
Vol. 310, Issue 5751, pp. 1099
DOI: 10.1126/science.310.5751.1099d

Microarrays reveal which genes crank up or slow down in diseases such as diabetes and cancer, but they yield a torrent of data that leaves many researchers feeling swamped. A new site called L2L (for “list-to-list”) from the University of Washington, Seattle, can help scientists cope with the flood. Users plug in their lists of regulated genes, and L2L compares them to more than 350 other lists compiled from published microarray papers. The output highlights common patterns of gene expression that suggest underlying molecular mechanisms. L2L can help researchers tease apart the effects of complex diseases on gene activity.

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