PerspectiveCell Biology

Twists in the Tale of the Aging Yeast

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Science  18 Nov 2005:
Vol. 310, Issue 5751, pp. 1124-1125
DOI: 10.1126/science.1121310

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Aging limits the number of divisions available to cells and the chronological life span of nondividing cells. In his Perspective, Rine discusses recent findings that caloric restriction, SIR2, and its molecular cousins, play conserved roles in aging. However, expectations of a simple unified model linking caloric restriction and aging through Sir2 protein's NADcofactor are now on hold.