Two Genes Link Two Distinct Psychoses

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Science  18 Nov 2005:
Vol. 310, Issue 5751, pp. 1128-1129
DOI: 10.1126/science.1121114

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Disrupted in schizophrenia 1 (DISC1), the first gene directly linked to schizophrenia, appears to regulate neuronal growth and migration. In their Perspective, Sawa and Snyder discuss the study by Millar et al. that reports the interaction of DISC1 with the enzyme phosphodiesterase 4B (PDE4B). PDE4B is now reported as aberrant in a schizophrenic family. The interaction of the two proteins controls PDE4B activity and may modulate mood and mentation both physiologically and pathophysiologically.