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Cancer-Suppressing Enzyme Adds a Link to Type 2 Diabetes

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Science  25 Nov 2005:
Vol. 310, Issue 5752, pp. 1259
DOI: 10.1126/science.310.5752.1259a

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Summary

An enzyme known as LKB1, discovered about 7 years ago as the product of a tumor-suppressor gene, is now turning out to be a key regulator of the body's metabolic activities, including its handling of glucose--a discovery that connects LKB1 to type 2 diabetes and may explain its link to cancer. The work is published online this week by Science (www.sciencemag.org/cgi/content/abstract/1120781). (Read more.)