PerspectiveDevelopmental Biology

Encountering MicroRNAs in Cell Fate Signaling

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Science  25 Nov 2005:
Vol. 310, Issue 5752, pp. 1288-1289
DOI: 10.1126/science.1121566

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The recent discovery of short regulatory RNAs called microRNAs has expanded our understanding of the regulation of gene expression, yet little is known about the role of microRNAs in developmental signaling pathways. In their Perspective, Karp and Ambros discuss a new study by Yoo and Greenwald that finds a microRNA to be a direct target of LIN-12/Notch signaling. This influences cell fate decisions during C. elegans development and may extend to other organisms, because the Notch signaling pathway is highly conserved.