Tipping the Scales Toward More Effective Antibodies

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Science  02 Dec 2005:
Vol. 310, Issue 5753, pp. 1442-1443
DOI: 10.1126/science.1122009

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Immunoglobulin G molecules, key mediators of immune protection and burgeoning therapeutic reagents, exist in different forms or subclasses. In her Perspective, Woof discusses new work by Nimmerjahn and Ravetch that reveals how, in some settings, the in vivo functional capabilities of each subclass may be predicted on the basis of differential interaction with specific cellular Fc receptors.