PerspectiveCell Biology

Keeping Survivin Nimble at Centromeres in Mitosis

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Science  02 Dec 2005:
Vol. 310, Issue 5753, pp. 1443-1444
DOI: 10.1126/science.1121952

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Ubiquitin is well known as a grim reaper that marks proteins for destruction. In his Perspective, Earnshaw discusses a study by Vong et al. that reports a new aspect of ubiquitin function--regulation of the dynamic behavior of the chromosomal passenger protein survivin during mitosis. If survivin carries either too little or too much polyubiquitin, survivin dynamics at centromeres are perturbed, and chromosome segregation is disrupted.