DATABASES: Phospho Finder

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Science  09 Dec 2005:
Vol. 310, Issue 5754, pp. 1593
DOI: 10.1126/science.310.5754.1593e

When cells need to switch a protein on or off, they often affix a phosphate group to the molecule. This process, known as phosphorylation, is important for governing protein activity and often goes awry in cancer and other diseases. To find out where phosphates glom onto a particular protein, check out Phospho-Site from the Beverly, Massachusetts—based company Cell Signaling Technology. Users enter the name of a mouse or human protein, and the site pin-points which amino acids pick up phosphates. The output often specifies how modifications at different positions alter the protein's function. Data gleaned from the literature are free, but access to the company's experimental findings may require a subscription.

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