On the Origins of Novelty and Variation

Science  09 Dec 2005:
Vol. 310, Issue 5754, pp. 1619-1620
DOI: 10.1126/science.1119727

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The Plausibility of Life. Resolving Darwin's Dilemma. By Marc W. Kirschner and John C. Gerhart. Yale University Press, New Haven, CT, 2005. 330 pp. $30, £18.95. ISBN 0-300-10865-6.

The authors hold that the accumulation of small genetic mutations over time does not explain the variety and complexity of life. Instead, they propose "facilitated variation" to account for the conversion of random genetic change into complex innovations.