Brevia

Increase in Activity During Calorie Restriction Requires Sirt1

See allHide authors and affiliations

Science  09 Dec 2005:
Vol. 310, Issue 5754, pp. 1641
DOI: 10.1126/science.1118357

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Abstract

Sir2 (silent information regulator 2) is a nicotinamide adenine dinucletide‐dependent deacetylase required for longevity due to calorie restriction in yeast and Drosophila. In mammals, calorie restriction induces a complex pattern of physiological and behavioral changes. Here we report that the mammalian Sir2 ortholog, Sirt1, is required for the induction of a phenotype by calorie restriction in mice.

View Full Text