Increase in Activity During Calorie Restriction Requires Sirt1

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Science  09 Dec 2005:
Vol. 310, Issue 5754, pp. 1641
DOI: 10.1126/science.1118357

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Sir2 (silent information regulator 2) is a nicotinamide adenine dinucletide‐dependent deacetylase required for longevity due to calorie restriction in yeast and Drosophila. In mammals, calorie restriction induces a complex pattern of physiological and behavioral changes. Here we report that the mammalian Sir2 ortholog, Sirt1, is required for the induction of a phenotype by calorie restriction in mice.

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