Linking NO Production and Prostaglandin Synthesis in Inflammation

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Science  23 Dec 2005:
Vol. 310, Issue 5756, pp. 1865
DOI: 10.1126/science.310.5756.1865m

Principal inflammatory responses in mammals include the induction of nitric oxide and prostaglandin synthesis in cells of the immune system. Kim et al. (p. 1966) report that the enzymes that produce these molecules, nitric oxide synthase and cyclooxygenase-2, respectively, interact in macrophage cells. Nitric oxide synthase delivers NO to cyclooxygenase-2. This modification of cyclooxygenase-2 by nitric oxide, known as S-nitrosylation, activates the enzyme. This synergism between the two systems may help in the design of potential novel anti-inflammatory drugs.

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