The Tick-Tock of Aging?

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Science  23 Dec 2005:
Vol. 310, Issue 5756, pp. 1911-1913
DOI: 10.1126/science.1122816

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lin-4, an evolutionarily conserved microRNA, and its regulatory target lin-14, encoding a nuclear protein, constitute a biological timing mechanism that advances Caenorhabditis elegans larval development. In his Perspective, Antebi discusses the report by Boehm and Slack that shows how these components may also regulate adult longevity. The microRNA and its target may work through DAF-16/FOXO, a forkhead transcription factor that extends life in diverse species. Hence, biological timers may regulate aging.