Cell Biology

Attracting a Blood Supply

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Science  06 Jan 2006:
Vol. 311, Issue 5757, pp. 16
DOI: 10.1126/science.311.5757.16c

Tissue growth and repair require the generation of new blood vessels through the process of angiogenesis. Because cell death and angiogenesis have been shown to be related, Weihua et al. examined whether apoptotic cells are involved in initiating the angiogenic response. When apoptotic tumor cells were cultured with endothelial cells, the nonproliferating endothelial cells began sprouting toward the apoptotic cells. As cells go through apoptosis, they display an increase in fixed negative charge on the cell surface, and endothelial cell sprouting was stimulated by this electrostatic interaction. — BAP

Cancer Res. 65, 11529 (2005).

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