Contents

03 February 2006
Vol 311, Issue 5761

About The Cover

Cover image expansion

COVER The structure of the hepatitis C virus NS5A-5B natural substrate (yellow), bound to the active site of the NS3-4A protease (blue), has formed the basis for designing novel protease inhibitors that directly interfere with replication of this virus. This image shows the shallow, solvent-exposed binding groove of the NS3-4A enzyme. The Gordon Research Conference on Medicinal Chemistry will be held from 6 to 11 August 2006 at Colby Sawyer College, New London, NH. The schedules for the 2006 Gordon Research Conferences begin on page 676. Image: James Griffith