PerspectiveCell Biology

The Stress of Finding NEMO

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Science  24 Feb 2006:
Vol. 311, Issue 5764, pp. 1110-1111
DOI: 10.1126/science.1124540

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A cell's response to damaged DNA is triggered when two proteins leave the nucleus and converge upon a signaling complex in the cytoplasm. This activates a key transcription factor that then moves into the nucleus to promote cell survival.