Five Golden Rings

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Science  10 Mar 2006:
Vol. 311, Issue 5766, pp. 1382-1383
DOI: 10.1126/science.1125298

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The antibiotic nisin bears five rings of different sizes in its structure. The enzyme that catalyzes the five distinct cyclization reactions is flexible, yet stringent, enough to form each ring in the correct order and conformation.