Clues to the Virulence of H5N1 Viruses in Humans

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Science  17 Mar 2006:
Vol. 311, Issue 5767, pp. 1562-1563
DOI: 10.1126/science.1125998

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Why is H5N1 avian influenza so virulent? Genomic analysis of various isolates suggests that, in addition to two known surface proteins, a third previously unnoticed sequence in a small viral protein may contribute to virulence.