Seamless Proteins Tie Up Their Loose Ends

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Science  17 Mar 2006:
Vol. 311, Issue 5767, pp. 1563-1564
DOI: 10.1126/science.1125248

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Natural circular proteins found in bacteria, plants, and mammals show antimicrobial activity and exceptional stability, making them ideal templates for engineering better drugs. But just how they close into loops remains a mystery.