News of the WeekDRUG TRIALS

Violent Reaction to Monoclonal Antibody Therapy Remains a Mystery

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Science  24 Mar 2006:
Vol. 311, Issue 5768, pp. 1688-1689
DOI: 10.1126/science.311.5768.1688

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CAMBRIDGE, U.K.-- On 13 March, six healthy volunteers in a clinical trial were injected with a "superagonist," a drug meant to boost a type of T cell in the immune system, and soon all of them became violently ill. Exactly what triggered the reaction is not known. (Read more.)